Determining ofwhether a plug and the slug flow regimesregime using The Multi-Fluid VoF and SST k-ω turbulence models have been performedperforms more efficiently in a horizontal pipeline. The pipe length and diameter considered 6 m and 44 mm, respectively. The superficial velocities during the current study were set at 0.16, 1.64 & 3 (m/s) for the gas phase and 1 (m/s) for the liquid phase. The pressure and the velocity equations were solved together, utilizing the PIMPLE method in all cases of the present study. The numerical results showed that the applied multi-phase method was able to achieve an acceptable and promising qualitative consistency in predicting the flow regimes. The nose and tail zone of the gas slug and plug flow were simulated precisely, in comparison with those results obtained from the experimental observations. The chronologicalchronology of the slug and plug formation was also detected during the current investigation. Moreover, the calculation of the horizontal pipe’s pressure drop using Multi-Fluid VoF presented a 20 percent improvement. Comparison of the achieved results with the Lockhart-Martinelli correlation as well as experimental outcomes, is more acceptable than the VoF method. Notwithstanding the advantages as mentioned earlier, the Multi-Fluid VoF model significantly increased, both the simulation time as well as the associated costs.